Interferon-gamma induced exacerbation of systemic lupus erythematosus

J Rheumatol. 1990 Jun;17(6):831-2.


A patient with presumed rheumatoid arthritis based on clinical and serological evidence was subjected by her physician to interferon-gamma (IFN-gamma) therapy and developed a life threatening multiorgan flare of systemic lupus erythematosus (SLE). Pulse cyclophosphamide therapy in conjunction with plasmapheresis led to complete remission. Retrospective analysis of serum drawn before IFN-gamma was started revealed high DNA binding capacity. Thus, similar to observations in lupus-prone animals, IFN-gamma may have induced an exacerbation of preexisting SLE.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / blood
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / epidemiology
  • Female
  • Humans
  • Interferon-gamma / adverse effects*
  • Interferon-gamma / therapeutic use
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / epidemiology
  • Lupus Erythematosus, Systemic / pathology
  • Retrospective Studies


  • Interferon-gamma