The relevance of heat shock regulation in fungal pathogens of humans

Virulence. Jul-Aug 2010;1(4):330-2. doi: 10.4161/viru.1.4.12364.

Abstract

Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candida albicans / genetics
  • Candida albicans / metabolism
  • Candida albicans / pathogenicity
  • Candida albicans / physiology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation, Fungal
  • HSP90 Heat-Shock Proteins
  • Heat Shock Transcription Factors
  • Heat-Shock Proteins / metabolism
  • Heat-Shock Response*
  • Humans
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • HSF1 protein, human
  • HSP90 Heat-Shock Proteins
  • Heat Shock Transcription Factors
  • Heat-Shock Proteins
  • Transcription Factors