SUMOylation and bacterial pathogens

Virulence. 2010 Nov-Dec;1(6):532-4. doi: 10.4161/viru.1.6.13449. Epub 2010 Nov 1.


During infection, bacterial pathogens interfere with many different post-translational modifications of the host cell to promote their own survival and replication. By stimulating or counteracting host post-translational modifications, these pathogens may control locally and specifically the fate and function of host factors critical for the infection process. Besides phosphorylation or ubiquitylation, for which many examples of modulation by pathogens exist, a post-translational modification called SUMOylation was recently shown to be targeted by pathogenic bacteria.

MeSH terms

  • Bacteria / metabolism*
  • Bacteria / pathogenicity*
  • Bacterial Proteins / metabolism*
  • Humans
  • Listeria monocytogenes / genetics
  • Listeria monocytogenes / metabolism*
  • Listeria monocytogenes / pathogenicity
  • Small Ubiquitin-Related Modifier Proteins / metabolism*
  • Sumoylation*
  • Ubiquitin-Conjugating Enzymes / metabolism
  • Virulence Factors / metabolism*
  • Xanthomonas campestris / genetics
  • Xanthomonas campestris / metabolism
  • Xanthomonas campestris / pathogenicity


  • Bacterial Proteins
  • Small Ubiquitin-Related Modifier Proteins
  • Virulence Factors
  • Ubiquitin-Conjugating Enzymes