A prospective study of chemotherapy-induced febrile neutropenia in the South West London Cancer Network. Interpretation of study results in light of NCAG/NCEPOD findings

Br J Cancer. 2011 Feb 1;104(3):407-12. doi: 10.1038/sj.bjc.6606059. Epub 2010 Dec 21.

Abstract

Background: Chemotherapy-induced febrile neutropenia is a medical emergency complicating the treatment of many cancer patients. It is associated with considerable morbidity and mortality, as well as impacting on healthcare resources.

Methods: A prospective study of all cases of chemotherapy-induced febrile neutropenia in the South West London Cancer Network was conducted over a 4-month period. Factors including demographics, treatment history, management of febrile neutropenia and outcome were recorded.

Results and conclusion: Our results reflect those of the recent National Chemotherapy Advisory Group (NCEPOD, 2008)/National Confidential Enquiry into Patient Outcomes and Death reports (NCAG, 2009) and highlight the need for network-wide clinical care pathways to improve outcomes in this area.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / adverse effects*
  • Databases, Factual
  • Female
  • Fever / chemically induced
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / drug therapy*
  • Neutropenia / chemically induced*
  • Prospective Studies
  • Risk Factors
  • Young Adult

Substances

  • Antineoplastic Agents