Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Jan;12(1):60-70.
doi: 10.1038/nrm3031.

A Structural Overview of the Plasma Membrane Na+,K+-ATPase and H+-ATPase Ion Pumps

Affiliations
Review

A Structural Overview of the Plasma Membrane Na+,K+-ATPase and H+-ATPase Ion Pumps

J Preben Morth et al. Nat Rev Mol Cell Biol. .

Abstract

Plasma membrane ATPases are primary active transporters of cations that maintain steep concentration gradients. The ion gradients and membrane potentials derived from them form the basis for a range of essential cellular processes, in particular Na(+)-dependent and proton-dependent secondary transport systems that are responsible for uptake and extrusion of metabolites and other ions. The ion gradients are also both directly and indirectly used to control pH homeostasis and to regulate cell volume. The plasma membrane H(+)-ATPase maintains a proton gradient in plants and fungi and the Na(+),K(+)-ATPase maintains a Na(+) and K(+) gradient in animal cells. Structural information provides insight into the function of these two distinct but related P-type pumps.

Similar articles

See all similar articles

Cited by 91 articles

See all "Cited by" articles

References

    1. J Biol Chem. 1996 Feb 2;271(5):2470-7 - PubMed
    1. Biometals. 2007 Jun;20(3-4):233-48 - PubMed
    1. Mol Cells. 1998 Oct 31;8(5):606-13 - PubMed
    1. Am J Physiol Renal Physiol. 2006 Feb;290(2):F241-50 - PubMed
    1. J Biol Chem. 2008 May 23;283(21):14867-82 - PubMed

MeSH terms

Substances

LinkOut - more resources

Feedback