Menstrual migraine: therapeutic approaches

Ther Adv Neurol Disord. 2009 Sep;2(5):327-36. doi: 10.1177/1756285609335537.


The development of diagnostic criteria has enabled greater recognition of menstrual migraine as a highly prevalent and disabling condition meriting specific treatment. Although few therapeutic trials have yet been undertaken in accordance with the criteria, the results of those published to date confirm the efficacy of acute migraine drugs for symptomatic treatment. If this approach is insufficient, the predictability of attacks provides the opportunity for perimenstrual prophylaxis. Continuous contraceptive strategies provide an additional option for management, although clinical trial data are limited. Future approaches to treatment could explore the genomic and nongenomic actions of sex steroids.

Keywords: menstrual migraine; perimenstrual prophylaxis; therapy.