Duchenne muscular dystrophy models show their age

Cell. 2010 Dec 23;143(7):1040-2. doi: 10.1016/j.cell.2010.12.005.

Abstract

The lack of appropriate animal models has hampered efforts to develop therapies for Duchenne muscular dystrophy (DMD). A new mouse model lacking both dystrophin and telomerase (Sacco et al., 2010) closely mimics the pathological progression of human DMD and shows that muscle stem cell activity is a key determinant of disease severity.

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