Wnt signaling: multivesicular bodies hold GSK3 captive

Christof Niehrs; Sergio P Acebron

doi:10.1016/j.cell.2010.12.003

Wnt signaling: multivesicular bodies hold GSK3 captive

Cell. 2010 Dec 23;143(7):1044-6. doi: 10.1016/j.cell.2010.12.003.

Authors

Christof Niehrs¹, Sergio P Acebron

Affiliation

¹ German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Division of Molecular Embryology, Im Neuenheimer Feld 581, Heidelberg, Germany. niehrs@dkfz.de

PMID: 21183070
DOI: 10.1016/j.cell.2010.12.003

Abstract

Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.

Publication types

Comment