Novel antibacterial proteins from the microbial communities associated with the sponge Cymbastela concentrica and the green alga Ulva australis

Appl Environ Microbiol. 2011 Feb;77(4):1512-5. doi: 10.1128/AEM.02038-10. Epub 2010 Dec 23.


The functional metagenomic screening of the microbial communities associated with a temperate marine sponge and a green alga identified three novel hydrolytic enzymes with antibacterial activities. The results suggest that uncultured alpha- and gammaproteobacteria contain new classes of proteins that may be a source of antibacterial agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alphaproteobacteria / enzymology*
  • Animals
  • Anti-Bacterial Agents / biosynthesis*
  • DNA Transposable Elements
  • Gammaproteobacteria / enzymology*
  • Metagenomics
  • Microbial Consortia / genetics
  • Mutation
  • Porifera / microbiology*
  • Ulva / microbiology*


  • Anti-Bacterial Agents
  • DNA Transposable Elements