Novel antibacterial proteins from the microbial communities associated with the sponge Cymbastela concentrica and the green alga Ulva australis

Pui Yi Yung; Catherine Burke; Matt Lewis; Staffan Kjelleberg; Torsten Thomas

doi:10.1128/AEM.02038-10

Novel antibacterial proteins from the microbial communities associated with the sponge Cymbastela concentrica and the green alga Ulva australis

Appl Environ Microbiol. 2011 Feb;77(4):1512-5. doi: 10.1128/AEM.02038-10. Epub 2010 Dec 23.

Authors

Pui Yi Yung¹, Catherine Burke, Matt Lewis, Staffan Kjelleberg, Torsten Thomas

Affiliation

¹ Centre for Marine Bio-Innovation and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

Abstract

The functional metagenomic screening of the microbial communities associated with a temperate marine sponge and a green alga identified three novel hydrolytic enzymes with antibacterial activities. The results suggest that uncultured alpha- and gammaproteobacteria contain new classes of proteins that may be a source of antibacterial agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alphaproteobacteria / enzymology*
Animals
Anti-Bacterial Agents / biosynthesis*
DNA Transposable Elements
Gammaproteobacteria / enzymology*
Metagenomics
Microbial Consortia / genetics
Mutation
Porifera / microbiology*
Ulva / microbiology*

Substances

Anti-Bacterial Agents
DNA Transposable Elements