Hijacking solute carriers for proton-coupled drug transport

Physiology (Bethesda). 2010 Dec;25(6):364-77. doi: 10.1152/physiol.00027.2010.

Abstract

The physiological role of mammalian solute carrier (SLC) proteins is to mediate transmembrane movement of electrolytes, nutrients, micronutrients, vitamins, and endogenous metabolites from one cellular compartment to another. Many transporters in the small intestine, kidney, and solid tumors are H(+)-coupled, driven by local H(+)-electrochemical gradients, and transport numerous drugs. These transporters include PepT1 and PepT2 (SLC15A1/2), PCFT (SLC46A1), PAT1 (SLC36A1), OAT10 (SLC22A13), OATP2B1 (SLCO2B1), MCT1 (SLC16A1), and MATE1 and MATE2-K (SLC47A1/2).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiporters / metabolism*
  • Biological Transport
  • Humans
  • Hydrogen-Ion Concentration
  • Intestine, Small / metabolism
  • Kidney Tubules, Proximal / metabolism
  • Neoplasms / metabolism
  • Pharmaceutical Preparations / metabolism*
  • Protons
  • Symporters / metabolism*

Substances

  • Antiporters
  • Pharmaceutical Preparations
  • Protons
  • Symporters