Crosstalk of reactive oxygen species and NF-κB signaling

Cell Res. 2011 Jan;21(1):103-15. doi: 10.1038/cr.2010.178. Epub 2010 Dec 28.


NF-κB proteins are a family of transcription factors that are of central importance in inflammation and immunity. NF-κB also plays important roles in other processes, including development, cell growth and survival, and proliferation, and is involved in many pathological conditions. Reactive Oxygen Species (ROS) are created by a variety of cellular processes as part of cellular signaling events. While certain NF-κB-regulated genes play a major role in regulating the amount of ROS in the cell, ROS have various inhibitory or stimulatory roles in NF-κB signaling. Here we review the regulation of ROS levels by NF-κB targets and various ways in which ROS have been proposed to impact NF-κB signaling pathways.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Antioxidants / metabolism
  • Humans
  • NF-kappa B / metabolism*
  • NF-kappa B / physiology
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction


  • Antioxidants
  • NF-kappa B
  • Reactive Oxygen Species