Vitamin d and multiple sclerosis: correlation, causality, and controversy

Joost Smolders

doi:10.4061/2011/629538

Vitamin d and multiple sclerosis: correlation, causality, and controversy

Autoimmune Dis. 2010 Oct 5:2011:629538. doi: 10.4061/2011/629538.

Author

Joost Smolders¹

Affiliation

¹ Division of Clinical and Experimental Immunology, Department of Internal Medicine and School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

Abstract

The last years, many studies reported associations between correlates of vitamin D exposure and several correlates of multiple sclerosis (MS) disease activity. This review discusses studies on vitamin D status, Expanded Disability Status Scale (EDSS) score, and relapse activity of MS. Furthermore, several considerations for intervention studies on vitamin D supplementation in MS are provided.