The effect of treatment with interferon-gamma on type II collagen-induced arthritis

Clin Exp Immunol. 1990 Sep;81(3):441-5. doi: 10.1111/j.1365-2249.1990.tb05353.x.


We have investigated the effects of recombinant murine interferon-gamma (rIFN-gamma) on type II collagen-induced arthritis (CA) in DBA/l mice. Therapeutic as well as prophylactic treatment with subcutaneous rIFN-gamma, at 10(5) U/mouse six times a week, inhibited the development of CA without any obvious side effects. The accompanying suppression of anti-CII antibody responses may partly explain the inhibition of CA by rIFN-gamma. The possible role of the anti-inflammatory effect of systemic IFN-gamma in the inhibition of CA is discussed.

MeSH terms

  • Animals
  • Arthritis / immunology
  • Arthritis / prevention & control
  • Arthritis / therapy*
  • Collagen / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hypersensitivity, Delayed / immunology
  • Immunization
  • Immunoglobulin G / biosynthesis
  • Interferon-gamma / therapeutic use*
  • Mice
  • Mice, Inbred DBA
  • Recombinant Proteins


  • Immunoglobulin G
  • Recombinant Proteins
  • Interferon-gamma
  • Collagen