Genetic control of Candida albicans biofilm development

Nat Rev Microbiol. 2011 Feb;9(2):109-18. doi: 10.1038/nrmicro2475. Epub 2010 Dec 29.

Abstract

Candida species cause frequent infections owing to their ability to form biofilms - surface-associated microbial communities - primarily on implanted medical devices. Increasingly, mechanistic studies have identified the gene products that participate directly in the development of Candida albicans biofilms, as well as the regulatory circuitry and networks that control their expression and activity. These studies have uncovered new mechanisms and signals that govern C. albicans biofilm development and associated drug resistance, thus providing biological insight and therapeutic foresight.

Publication types

  • Review

MeSH terms

  • Biofilms*
  • Candida albicans / genetics*
  • Candida albicans / growth & development*
  • Environment
  • Extracellular Matrix / genetics
  • Genes, Fungal / genetics*
  • Quorum Sensing / genetics