C. elegans star proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development

Adv Exp Med Biol. 2010;693:106-22. doi: 10.1007/978-1-4419-7005-3_8.


A comprehensive understanding of the C. elegans STAR proteins GLD-1 and ASD-2 is emerging from a combination of studies. Those employing genetic analysis reveal in vivo function, others involving biochemical approaches pursue the identification of mRNA targets through which these proteins act. Lastly, mechanistic studies provide the molecular pathway of target mRNA regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / growth & development*
  • Caenorhabditis elegans / metabolism*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism*
  • Gene Expression Regulation, Developmental
  • RNA, Helminth / genetics
  • RNA, Helminth / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*


  • ASD-2 protein, C elegans
  • Caenorhabditis elegans Proteins
  • GLD-1 protein, C elegans
  • RNA, Helminth
  • RNA-Binding Proteins