Two new triterpenoid acids from Kadsura coccinea

Arch Pharm Res. 2010 Dec;33(12):1933-6. doi: 10.1007/s12272-010-1207-0. Epub 2010 Dec 30.

Abstract

An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid (1) and 3-hydroxy-neokadsuranic acid A (2). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC(50) values ranging from 3.01 to 18.08 μg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • HCT116 Cells
  • HL-60 Cells
  • Hep G2 Cells
  • Humans
  • Kadsura*
  • Magnetic Resonance Spectroscopy
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Roots
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology

Substances

  • 3-hydroxy-12-hydroxyl coccinic acid
  • 3-hydroxy-neokadsuranic acid A
  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Triterpenes