Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome

Am J Hum Genet. 2011 Jan 7;88(1):92-8. doi: 10.1016/j.ajhg.2010.12.002. Epub 2010 Dec 30.


Waardenburg anophthalmia syndrome, also known as microphthalmia with limb anomalies, ophthalmoacromelic syndrome, and anophthalmia-syndactyly, is a rare autosomal-recessive developmental disorder that has been mapped to 10p11.23. Here we show that this disease is heterogeneous by reporting on a consanguineous family, not linked to the 10p11.23 locus, whose two affected children have a homozygous mutation in SMOC1. Knockdown experiments of the zebrafish smoc1 revealed that smoc1 is important in eye development and that it is expressed in many organs, including brain and somites.

MeSH terms

  • Adult
  • Base Sequence
  • Child
  • Consanguinity
  • Eye / growth & development
  • Female
  • Fingers / diagnostic imaging
  • Fingers / growth & development
  • Genes, Recessive
  • Humans
  • Male
  • Molecular Sequence Data
  • Mutation*
  • Osteonectin / genetics*
  • Pedigree
  • Radiography
  • Waardenburg Syndrome / genetics


  • Osteonectin
  • SMOC1 protein, human

Supplementary concepts

  • Anophthalmos with limb anomalies

Associated data

  • GENBANK/HQ665031