Genetic modification of T cells

Biol Blood Marrow Transplant. 2011 Jan;17(1 Suppl):S15-20. doi: 10.1016/j.bbmt.2010.09.019.


Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adoptive Transfer / methods*
  • Adoptive Transfer / standards
  • Humans
  • Immune Evasion
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / transplantation*
  • Transfection*
  • Tumor Escape