NF-κB, Inflammation, and Metabolic Disease

Cell Metab. 2011 Jan 5;13(1):11-22. doi: 10.1016/j.cmet.2010.12.008.

Abstract

Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation / genetics
  • Inflammation / physiopathology*
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism
  • Macrophages / immunology
  • Macrophages / pathology
  • Metabolic Diseases / genetics
  • Metabolic Diseases / immunology
  • Metabolic Diseases / metabolism
  • Metabolic Diseases / physiopathology*
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / immunology
  • NF-kappa B / physiology*
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors
  • Protein-Serine-Threonine Kinases / physiology

Substances

  • Inflammation Mediators
  • NF-kappa B
  • Protein-Serine-Threonine Kinases
  • NF-kappa B kinase