Reassortment Between Seasonal and Swine-Origin H1N1 Influenza Viruses Generates Viruses With Enhanced Growth Capability in Cell Culture

Virus Res. 2011 Mar;156(1-2):147-50. doi: 10.1016/j.virusres.2010.12.014. Epub 2010 Dec 31.


One year after the emergence of the 2009 influenza (H1N1) pandemic, most cases have been relatively mild; however, the possibility of enhanced viral growth ability by reassortment with seasonal viruses cannot be overlooked. Here, we show that reassortant viruses containing a seasonal H1 HA and swine-origin NA and M genes have enhanced virus growth over their wild-type parental viruses. The emergence of such viruses in nature could, therefore, represent a threat.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Chickens
  • Erythrocytes / virology
  • Genes, Viral / genetics
  • Guinea Pigs
  • HEK293 Cells
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / physiology*
  • Influenza, Human / virology*
  • Orthomyxoviridae Infections / virology
  • Reassortant Viruses / genetics
  • Reassortant Viruses / physiology*
  • Receptors, Virus / metabolism
  • Turkeys


  • Receptors, Virus