Amino acids and diabetes: implications for endocrine, metabolic and immune function

Front Biosci (Landmark Ed). 2011 Jan 1;16:315-39. doi: 10.2741/3690.

Abstract

Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / metabolism
  • Amino Acids / pharmacology
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Endothelium, Vascular / physiopathology
  • Glucagon-Secreting Cells / drug effects
  • Glucagon-Secreting Cells / metabolism
  • Glucose / metabolism
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Insulin-Secreting Cells / drug effects
  • Insulin-Secreting Cells / metabolism*
  • Liver / physiopathology
  • Lymphocytes / drug effects
  • Lymphocytes / immunology
  • Muscle, Skeletal / physiopathology
  • Neutrophils / drug effects
  • Neutrophils / immunology

Substances

  • Amino Acids
  • Insulin
  • Glucose