Crystalline calcium carbonate and hydrogels as microenvironment for stem cells

Front Biosci (Landmark Ed). 2011 Jan 1;16:458-71. doi: 10.2741/3698.


Stem cell development and fate decisions are dictated by the microenvironment in which the stem cell is embedded. Among the advanced goals of tissue engineering is the creation of a microenvironment that will support the maintenance and differentiation of the stem cell--based on embryonic and adult stem cells as potent, cellular sources--for a variety of clinical applications. This review discusses some of the approaches used to create regulatory and instructive microenvironments for the directed differentiation of mesenchymal stem cells (MSCs) using three-dimensional crystalline calcium carbonate biomaterials of marine origin combined with a hydrated gel based on hyaluronan.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthozoa
  • Biocompatible Materials
  • Calcium Carbonate*
  • Carbohydrate Conformation
  • Cell Differentiation
  • Hyaluronic Acid*
  • Hydrogels
  • Stem Cells / cytology*
  • Stem Cells / physiology
  • Tissue Engineering / methods*


  • Biocompatible Materials
  • Hydrogels
  • Hyaluronic Acid
  • Calcium Carbonate