Myb proteins: angels and demons in normal and transformed cells

Front Biosci (Landmark Ed). 2011 Jan 1;16:1109-31. doi: 10.2741/3738.

Abstract

A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor regulates the expression of hundreds of genes and is in turn regulated by numerous pathways and protein interactions. However, the most unique feature of c-Myb is that it can be converted into an oncogenic transforming protein through a few mutations that completely change its activity and specificity. The c-Myb protein is a myriad of interactions and activities rolled up in a protein that controls proliferation and differentiation in many different cell types. Here we discuss the background and recent progress that have led to a better understanding of this complex protein, and outline the questions that have yet to be answered.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alternative Splicing / physiology
  • Animals
  • Cell Cycle Proteins / metabolism
  • Cell Differentiation / drug effects
  • Cell Proliferation / drug effects
  • Cell Transformation, Viral / physiology
  • DNA-Binding Proteins / metabolism
  • Humans
  • Leukemia / genetics
  • MicroRNAs / physiology
  • Neoplasms / genetics
  • Neoplasms / physiopathology
  • Oncogene Proteins v-myb / physiology*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-myb / genetics
  • Proto-Oncogene Proteins c-myb / physiology*
  • Signal Transduction
  • Stem Cells / drug effects
  • Trans-Activators / metabolism
  • Wnt Proteins / physiology

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • MYBL1 protein, human
  • MYBL2 protein, human
  • MicroRNAs
  • Oncogene Proteins v-myb
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myb
  • Trans-Activators
  • Wnt Proteins