NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target

Front Biosci (Landmark Ed). 2011 Jan 1;16:1172-85. doi: 10.2741/3782.

Abstract

Lung cancer ranks as the first malignant tumor killer worldwide. Despite the knowledge that carcinogens from tobacco smoke and the environment constitute the main causes of lung cancer, the mechanisms for lung carcinogenesis are still elusive. Cancer development and progression depend on the balance between cell survival and death signals. Common cell survival signaling pathways are activated by carcinogens as well as by inflammatory cytokines, which contribute substantially to cancer development. As a major cell survival signal, nuclear factor-kappaB (NF-kappaB) is involved in multiple steps in carcinogenesis and in cancer cell's resistance to chemo- and radio-therapy. Recent studies with animal models and cell culture systems have established the links between NF-kappaB and lung carcinogenesis, highlighting the significance of targeting NF-kappa signaling pathway for lung cancer treatment and chemoprevention. In this review, we summarize progresses in understanding the NF-kappaB pathway in lung cancer development as well as in modulating NF-kappaB for lung cancer prevention and therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma of Lung
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Apoptosis / drug effects
  • Carcinogens / pharmacology
  • Cell Proliferation / drug effects
  • Chemoprevention
  • Humans
  • Inflammation / complications
  • Inflammation / etiology
  • Lung Neoplasms* / chemically induced
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / pathology
  • Lung Neoplasms* / prevention & control
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / drug effects
  • NF-kappa B / physiology*
  • Neovascularization, Pathologic
  • Proteasome Endopeptidase Complex
  • Signal Transduction / drug effects
  • Signal Transduction / physiology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Carcinogens
  • NF-kappa B
  • Proteasome Endopeptidase Complex