Effects of omega-3 polyunsaturated fatty acids on cardiac myocyte protection

Front Biosci (Landmark Ed). 2011 Jan 1;16:1833-43. doi: 10.2741/3825.


Many epidemiologic, observational and randomized human clinical trials have demonstrated beyond doubt the protective cardiovascular effects of omega-3 polyunsaturated fatty acids (PUFAs). Cardiac myocytes protection by omega-3 PUFAs involves several mechanisms which might have a synergistic effect. This review provides a summary of the in vitro and in vivo effects of omega-3 PUFAs on cardiac myocytes health and reports the outcome of a number of clinical trials in patients consuming omega-3 PUFAs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiotonic Agents / therapeutic use
  • Cardiovascular Diseases / prevention & control*
  • Fatty Acids, Omega-3 / therapeutic use*
  • Humans
  • Myocytes, Cardiac / drug effects*
  • Sodium Channels / drug effects


  • Cardiotonic Agents
  • Fatty Acids, Omega-3
  • Sodium Channels