Single Nucleotide Polymorphisms in IL-4Ra, IL-13 and STAT6 Genes Occurs in Brain Glioma

Front Biosci (Elite Ed). 2011 Jan 1;3:33-45. doi: 10.2741/e217.

Abstract

Gliomas are aggressive brain tumor. Association studies were consistent for an inverse association between asthma and allergic conditions (IgE levels) and risk of glioma. Studies reported that the IL-4Ra, IL-13 and STAT6 genes played a relatively strong role in IgE production or allergy. This population-based case-control study aimed to find potential association between single nucleotide polymorphisms IL-13rs20541, IL-4Rars1801275 and glioma susceptibility in population, as well as STAT6 rs1059513 and STAT6 rs324015. Among non-smokers, homozygote GG of STAT6 4610A/G showed an increased association with risk of glioma compared with AA (adjusted OR=1.691, 95%CI=1.152-2.481, p=0.007, corrected p=0.028), and the haplotype with A allele at rs1059513 and G allele at rs324015 was revealed to increase glioma risk significantly (OR=1.321,95%CI= 1.081-1.614, p=0.007,corrected p=0.028). GG genotype of STAT6 4610A/G was a significant risk factor compared with AA in glioblastoma (adjusted OR=1.856, 95%CI=1.153-2.987, p=0.011, corrected p=0.044). GG of STAT6 4610A/G was significantly related to increased WHO IV risk compared with AA (adjusted OR=1.591,95%CI=1.030-2.459, p=0.036, corrected p=0.144). Interaction between IL-13 Arg130Gln and IL-4Ra Gln576Arg was observed in decreasing glioma risk (p=0.045).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthma / metabolism
  • Brain Neoplasms / genetics*
  • Case-Control Studies
  • China
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Glioma / genetics*
  • Humans
  • Hypersensitivity / metabolism
  • Immunoglobulin E / metabolism
  • Interleukin-13 / genetics*
  • Logistic Models
  • Odds Ratio
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, Interleukin-4 / genetics*
  • Risk Factors
  • STAT6 Transcription Factor / genetics*
  • Surveys and Questionnaires

Substances

  • Interleukin-13
  • Receptors, Interleukin-4
  • STAT6 Transcription Factor
  • Immunoglobulin E