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Review
. 2011 Jan 1;3:291-300.
doi: 10.2741/e244.

Surfactant Proteins A and D in Pregnancy and Parturition

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Review

Surfactant Proteins A and D in Pregnancy and Parturition

Ajit Kumar Yadav et al. Front Biosci (Elite Ed). .

Abstract

Surfactant proteins A and D have extra-pulmonary expression at various mucosal sites including the reproductive tract. Reproductive tissues require a fine immune balance, strong enough to keep infection at a bay and at the same time, subtle enough to support an allogeneic fetus throughout the pregnancy. Roles of SP-A and SP-D have been studied in depth and include immunoregulatory function, besides strengthening the innate immune system against various pathogens in the lungs. Interestingly, levels of SP-A and SP-D in the amniotic fluid increase progressively in pregnancy. SP-A has been implicated in the induction of parturition. The present review elaborates the plausible roles of SP-A and SP-D in pregnancy maintenance and future applications.

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