Skin cancer chemoprevention by α-santalol

Front Biosci (Schol Ed). 2011 Jan 1;3:777-87. doi: 10.2741/s186.

Abstract

Alpha-santalol, a naturally occurring terpenoid, has been shown to have chemopreventive effects on both 7, 12-dimethylbenz(a)anthracene (DMBA)-initiated and 12-O- tetradecanoylphorbol-13-acetate (TPA)-promoted skin cancer development in CD-1 and SENCAR mice, and UVB-induced skin cancer developments in SKH-1 hairless mice in a concentration-dependent manner. Studies have demonstrated that α-santalol could be effective against skin carcinogenesis through both induction of apoptosis via caspase activation together with dissipation of mitochondria membrane potential and cytochrome c release in A431 cells, and inhibition of cell growth via induction of G2/M phase arrest in both A431 cells and melanoma UACC-62 cells by altering multiple cell cycle regulatory proteins and complexes. This review summarizes the chemopreventive effects and molecular mechanisms of α-santalol on skin cancer development in both animal models and skin cancer cell lines.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / toxicity
  • Animals
  • Apoptosis / drug effects
  • Cell Cycle / drug effects
  • Cell Line, Tumor
  • Drugs, Chinese Herbal / therapeutic use*
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Phytotherapy / methods*
  • Plant Oils / chemistry*
  • Polycyclic Sesquiterpenes
  • Santalum / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology*
  • Sesquiterpenes / therapeutic use*
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / prevention & control*
  • Tetradecanoylphorbol Acetate / toxicity

Substances

  • Drugs, Chinese Herbal
  • Plant Oils
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • santalol
  • 9,10-Dimethyl-1,2-benzanthracene
  • Tetradecanoylphorbol Acetate
  • sandalwood oil