A 52-week study of safety and efficacy of calcium hydroxylapatite for rejuvenation of the aging hand

J Drugs Dermatol. 2011 Jan;10(1):47-51.


Objectives: the investigator sought to determine whether calcium hydroxylapatite (CaHA) could be used as dermal filler for replacement of volume loss in aging hands.

Methods: the principal investigator injected 1.3 mL of CaHA into the dorsal side of both hands (BH) of 10 female patients (57-68 years of age), for full correction. Investigator, independent evaluator and subjects assessed results at four time points.

Results: safety. Brief and minor adverse events were reported. Efficacy. Wrinkle severity, improvement and patient satisfaction were assessed. Wrinkle Severity. Less severity was noted at 12 months than at baseline. Improvement. At nine months 80 percent of BH were rated as improved or better (IOB) and at 12 months 40 percent of right and 30 percent of left hands as IOB, approximating findings of the independent evaluator but at some variance from the subjects. Patient Satisfaction. At 12 months, 60 percent of subjects rated their results as "satisfactory" or better.

Conclusion: in this study, CaHA performed well, with a favorable safety and durability profile. This application expands treatment options in patients seeking rejuvenation of the aging hand and face.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Biocompatible Materials / administration & dosage*
  • Cosmetic Techniques / adverse effects*
  • Durapatite / administration & dosage*
  • Female
  • Follow-Up Studies
  • Hand* / pathology
  • Hand* / physiology
  • Humans
  • Injections, Subcutaneous
  • Middle Aged
  • Rejuvenation* / physiology
  • Skin Aging / drug effects*
  • Skin Aging / pathology
  • Skin Aging / physiology
  • Treatment Outcome


  • Biocompatible Materials
  • Durapatite