Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss

Int J Pediatr Obes. 2011 Aug;6(3-4):236-43. doi: 10.3109/17477166.2010.544739. Epub 2011 Jan 3.

Abstract

Background: Insulin-like growth factor binding protein 1 (IGFBP-1) is a marker of insulin resistance. We hypothesized that IGFBP-1 is associated with the metabolic syndrome (MetS), which is related to insulin resistance.

Methods: We examined 51 obese Caucasian children (mean age 12.1 ? 2.3, 55% male, mean body mass index [BMI] 31.8 ? 4.8 kg/m(2)). Anthropometrical markers, pubertal stage, hepatic ultrasound, waist circumference, blood pressure, fasting serum IGFBP-1, IGFBP-3, IGF-I, adiponectin, leptin, transaminases, glucose, insulin, triglycerides, and HDL-cholesterol concentrations were determined at onset and the end of the one-year lifestyle intervention.

Results: In contrast to IGF-I and IGFBP-3, IGFBP-1 correlated significantly to most parameters of the MetS in cross-sectional (waist circumference: r = -0.45, triglycerides: r = -0.29; insulin: r = -0.31; HOMA: r = -0.30) and longitudinal analyses (? triglycerides: r = ?0.22; ? Insulin: r = ?0.25; ? HOMA: r = ?0.62). The association between changes of HOMA and changes of IGFBP-1 was stronger than the associations between changes of leptin or adiponectin, and changes of HOMA. The risk for the MetS was inversely related to IGFBP-1 levels (odds ratio:-0.05 per additional IGFBP-1 unit; 95% confidence interval: -0.08 up to -0.02; p = 0.019) in a multiple logistic regression analyses adjusted to BMI, pubertal stage, age, and gender. The nine obese children with the MetS had significantly lower IGFBP-1 levels (1.6 ? 1.3 ngm/l) than the 42 obese children without the MetS (4.0 ? 3.8 ng/ml). The eleven obese children with fatty liver assessed by ultrasound had significantly lower IGFBP-1 levels (1.5 ? 1.3 ngm/l) than the 40 obese children without fatty liver (4.2 ? 4.1 ng/ml).

Conclusion: The strong relationships between IGFBP-1, insulin resistance, and the MetS suggest that IGFBP-1 might be a promising marker for these entities in obesity. This study is registered at clinicaltrials.gov (NCT00435734).

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Biomarkers / blood
  • Blood Glucose / metabolism
  • Blood Pressure
  • Body Mass Index
  • Chi-Square Distribution
  • Child
  • Cross-Sectional Studies
  • European Continental Ancestry Group
  • Female
  • Humans
  • Insulin / blood
  • Insulin Resistance*
  • Insulin-Like Growth Factor Binding Protein 1 / blood*
  • Lipids / blood
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / ethnology
  • Metabolic Syndrome / etiology
  • Metabolic Syndrome / physiopathology
  • Obesity / blood
  • Obesity / complications
  • Obesity / ethnology
  • Obesity / physiopathology
  • Obesity / therapy*
  • Risk Assessment
  • Risk Factors
  • Risk Reduction Behavior*
  • Time Factors
  • Treatment Outcome
  • Waist Circumference
  • Weight Loss*

Substances

  • Biomarkers
  • Blood Glucose
  • IGFBP1 protein, human
  • Insulin
  • Insulin-Like Growth Factor Binding Protein 1
  • Lipids

Associated data

  • ClinicalTrials.gov/NCT00435734