Targeted therapies and thyroid cancer: an update

Anticancer Drugs. 2011 Aug;22(7):688-99. doi: 10.1097/CAD.0b013e32834319c7.


The treatment of metastatic, progressive thyroid cancer has evolved over recent years. New 'targeted' therapeutic approaches have been developed along with advances in the knowledge of thyroid carcinogenesis and the identification of tumor and endothelial targets. In recent years, results of targeted therapies have shown some benefit in refractory, progressive, differentiated, and medullary thyroid carcinomas but not, until recently, in undifferentiated thyroid carcinoma. We review here the different targeted therapies tested in thyroid cancers.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Carcinoma, Neuroendocrine
  • Drug Delivery Systems*
  • Endothelium / drug effects
  • Endothelium / metabolism
  • Humans
  • Neoplasm Metastasis
  • Thyroid Neoplasms / drug therapy*
  • Thyroid Neoplasms / pathology


  • Antineoplastic Agents

Supplementary concepts

  • Thyroid cancer, medullary