In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat

J Clin Invest. 1990 Oct;86(4):1369-74. doi: 10.1172/JCI114849.


It has been previously shown in vitro that the human immunodeficiency virus type 1 long terminal repeat (LTR) is activated by ultraviolet irradiation. In order to analyze if a similar effect could occur in vivo, transgenic mice carrying the lacZ gene under the control of the viral LTR were irradiated at 280-300 and 254 nm. These mice spontaneously expressed the transgene in the epidermis and the lens of both adults and embryos. Irradiations caused a significant increase in skin beta-galactosidase activity. This phenomenon might be involved in viral activation and could be of interest in regard to the skin pathology observed during an HIV infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gene Expression Regulation, Viral / radiation effects*
  • HIV Long Terminal Repeat / radiation effects*
  • Humans
  • Lac Operon
  • Mice
  • Mice, Transgenic
  • Skin / microbiology
  • Ultraviolet Rays
  • beta-Galactosidase / analysis


  • beta-Galactosidase