The expression of the TRPC2 channel in rodents appears largely restricted to neurons of the vomeronasal organ (VNO) and is detected at lower levels in few other tissues. The characteristics of TRPC2 expression, as well as the availability of the TRPC2 gene as a tool for genetic manipulation, has led to significant advances in understanding the biology of the vomeronasal organ and pheromone detection in rodents and across evolution.
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