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. 2011 Jan 5;30(1):3-4.
doi: 10.1038/emboj.2010.323.

Pseudouridylation Goes Regulatory

Free PMC article

Pseudouridylation Goes Regulatory

U Thomas Meier. EMBO J. .
Free PMC article


Ever since their discovery some 60 years ago, RNA modifications were considered constitutive. Now a paper in this issue of The EMBO Journal shows that environmental stimuli induce pseudouridylation of U2 snRNA at novel sites thus impacting pre-mRNA splicing. After the regulatory modification of protein and of DNA, that of RNA now adds another level of complexity to the cellular signalling landscape.

Conflict of interest statement

The author declares that he has no conflict of interest.


Figure 1
Figure 1
Inducible pseudouridylation of the spliceosomal snRNA U2 at novel sites 56 and 93 (red) by H/ACA RNA-dependent and -independent mechanisms impairs its function in pre-mRNA splicing. Isomerization of uridine to pseudouridine (inset), previously believed to be constitutive, occurs through 180° rotation of the base, yielding a carbon- (red) instead of a nitrogen-glycosidic bond and thus providing an additional opportunity for hydrogen bonding (green).

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