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Comparative Study
. 2011 Mar;22(3):479-85.
doi: 10.1007/s10552-010-9720-5. Epub 2011 Jan 5.

Papillary Thyroid Cancer Incidence Rates Vary Significantly by Birthplace in Asian American Women

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Free PMC article
Comparative Study

Papillary Thyroid Cancer Incidence Rates Vary Significantly by Birthplace in Asian American Women

Pamela L Horn-Ross et al. Cancer Causes Control. .
Free PMC article

Abstract

Objective: To investigate how birthplace influences the incidence of papillary thyroid cancer among Asian American women.

Methods: Birthplace- and ethnic-specific age-adjusted and age-specific incidence rates were calculated using data from the California Cancer Registry for the period 1988-2004. Birthplace was statistically imputed for 30% of cases using a validated imputation method based on age at Social Security number issuance. Population estimates were obtained from the US Census. Incidence rate ratios (IRR) and 95% confidence intervals (CI) were estimated for foreign-born vs. US-born women.

Results: Age-adjusted incidence rates of papillary thyroid cancer among Filipina (13.7 per 100,000) and Vietnamese (12.7) women were more than double those of Japanese women (6.2). US-born Chinese (IRR = 0.48, 95% CI: 0.40-0.59) and Filipina women (IRR = 0.74, 95% CI: 0.58-0.96) had significantly higher rates than those who were foreign-born; the opposite was observed for Japanese women (IRR = 1.55, 95% CI: 1.17-2.08). The age-specific patterns among all foreign-born Asian women and US-born Japanese women showed a slow steady increase in incidence until age 70. However, among US-born Asian women (except Japanese), substantially elevated incidence rates during the reproductive and menopausal years were evident.

Conclusions: Ethnic- and birthplace-variation in papillary thyroid cancer incidence can provide insight into the etiology of this increasingly common and understudied cancer.

Figures

Figure 1
Figure 1
Age-specific papillary thyroid cancer incidence rates (per 100,000) in white and black women, California 1988–2004.
Figure 2
Figure 2
Age-specific papillary thyroid cancer incidence rates (per 100,000) in Asian American women by birthplace, California 1988–2004. solid lines are US-born; dotted lines are foreign-born

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