Management of acute ischemic stroke: time is brain

Mo Med. Sep-Oct 2010;107(5):333-7.


Treatment of acute ischemic stroke is time dependent and technically challenging. Sixty-four percent of hospitals in the U.S. have never given intravenous (IV) tissue plasminogen activator (tPA) for stroke and 40% of the U.S. population lives in a county without a hospital that routinely treats eligible stroke victims with IV tPA. This, the second in a Missouri Medicine series on stroke, summarizes the available acute treatment options and the evolving role of neuro-imaging in directing therapeutic decisions.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Brain Ischemia / diagnosis
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / therapy
  • Drug Administration Routes
  • Fibrinolytic Agents / administration & dosage*
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Reperfusion Injury / prevention & control*
  • Stroke / diagnosis
  • Stroke / drug therapy*
  • Stroke / therapy
  • Time Factors
  • Tissue Plasminogen Activator / administration & dosage*
  • Tissue Plasminogen Activator / therapeutic use


  • Fibrinolytic Agents
  • Tissue Plasminogen Activator