Role of the nuclear lamina in genome organization and gene expression

Cold Spring Harb Symp Quant Biol. 2010;75:517-24. doi: 10.1101/sqb.2010.75.014. Epub 2011 Jan 5.

Abstract

The nuclear lamina is a major structural component of metazoan nuclei that has long been thought to provide an anchoring site for interphase chromosomes and have a role in gene regulation. Recent genome-wide mapping studies and functional experimental data strongly support these roles of the nuclear lamina. Here, we discuss new insights into various aspects of genome-nuclear lamina interactions, with emphasis on the links with gene regulation and with dynamics during cellular differentiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatin / metabolism
  • Chromosome Mapping
  • Embryonic Development / genetics
  • Gene Expression Regulation*
  • Gene Silencing
  • Genome / genetics*
  • Humans
  • Lamins / metabolism
  • Models, Biological
  • Nuclear Lamina / genetics*
  • Nuclear Pore / metabolism
  • Protein Binding
  • Stochastic Processes

Substances

  • Chromatin
  • Lamins