Abstract
A multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and tertiary amine is discovered, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good yields under mild conditions. In the reaction process, silver(I)-catalyzed intramolecular cyclization and copper(II)-catalyzed oxidation of an aliphatic C-H bond of tertiary amine in air are involved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemistry*
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Benzaldehydes / chemistry*
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Catalysis
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Copper / chemistry*
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Cyclization
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Heterocyclic Compounds, 3-Ring / chemical synthesis*
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Heterocyclic Compounds, 3-Ring / chemistry
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Isoquinolines / chemical synthesis*
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Isoquinolines / chemistry
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Molecular Structure
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Oxidation-Reduction
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Sulfonamides / chemistry*
Substances
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Amines
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Benzaldehydes
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Heterocyclic Compounds, 3-Ring
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Isoquinolines
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Pyrazoles
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Sulfonamides
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Copper