Impaired awareness of hypoglycaemia: a review

Diabetes Metab. 2010 Oct;36 Suppl 3:S64-74. doi: 10.1016/S1262-3636(10)70470-5.


Impaired awareness of hypoglycaemia (IAH) is an acquired complication of insulin therapy, which affects people with type 1 and insulin-treated type 2 diabetes mellitus, whereby the ability to perceive the onset of hypoglycaemia becomes diminished or absent. Deficiencies of the counter-regulatory hormonal responses to hypoglycaemia usually co-exist. The development of IAH and counter-regulatory failure greatly increases the risk of severe hypoglycaemia. Scoring systems have been developed that can be used in the clinical setting and assist with identification of this group of individuals at risk of severe hypoglycaemia. The mainstay of treatment of IAH is the scrupulous avoidance of hypoglycaemia.

Publication types

  • Review

MeSH terms

  • Brain Chemistry
  • Diabetes Mellitus / blood
  • Humans
  • Hypoglycemia / diagnosis*
  • Hypoglycemia / physiopathology
  • Magnetic Resonance Imaging