Aging by telomere loss can be reversed

Bruno Bernardes de Jesus; Maria A Blasco

doi:10.1016/j.stem.2010.12.013

Aging by telomere loss can be reversed

Cell Stem Cell. 2011 Jan 7;8(1):3-4. doi: 10.1016/j.stem.2010.12.013.

Authors

Bruno Bernardes de Jesus¹, Maria A Blasco

Affiliation

¹ Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid E-28029, Spain.

PMID: 21211774
DOI: 10.1016/j.stem.2010.12.013

Abstract

Recently in Nature, Jaskelioff et al. (2010) demonstrated that multiple aging phenotypes in a mouse model of accelerated telomere loss can be reversed within 4 weeks of reactivating telomerase. This raises the major question of whether physiological aging, likely caused by a combination of molecular defects, may also be reversible.

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