DNA-damage response in tissue-specific and cancer stem cells

Cell Stem Cell. 2011 Jan 7;8(1):16-29. doi: 10.1016/j.stem.2010.12.012.


Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to address DNA damage, and describe how these mechanisms can impact SC genomic integrity by potentially promoting aging, tissue atrophy, and/or cancer development. Finally, we will discuss how similar mechanisms operate in cancer stem cells (CSCs) and can mediate resistance to chemo- and radiotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging
  • Animals
  • DNA Damage / physiology*
  • DNA Repair
  • Humans
  • Neoplasms / therapy*
  • Neoplastic Stem Cells / cytology*
  • Neoplastic Stem Cells / metabolism
  • Signal Transduction