Abstract
RNA-directed DNA methylation (RdDM) is a small RNA-mediated epigenetic modification in plants. We report here the identification of DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) in a forward screen for mutants defective in RdDM in Arabidopsis thaliana. The finding of a mutation in the presumptive active site argues in favor of direct catalytic activity for DRM2.
© 2011 by the Genetics Society of America
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Arabidopsis / genetics*
-
Arabidopsis / metabolism
-
DNA Methylation / genetics*
-
Methyltransferases / genetics*
-
Methyltransferases / metabolism
-
Molecular Sequence Data
-
Point Mutation
-
RNA / genetics*
-
RNA / metabolism*
-
RNA, Small Interfering / genetics
Substances
-
RNA, Small Interfering
-
RNA
-
Methyltransferases
-
DRM2 protein, Arabidopsis