CRL4Cdt2: master coordinator of cell cycle progression and genome stability

Cell Cycle. 2011 Jan 15;10(2):241-9. doi: 10.4161/cc.10.2.14530. Epub 2011 Jan 15.


Polyubiquitin-mediated degradation of proteins plays an essential role in various physiological processes including cell cycle progression, transcription and DNA replication and repair. Increasing evidence supports a vital role for the E3 ubiquitin ligase cullin-4, in conjunction with the substrate recognition factor Cdt2 (CRL4Cdt2), for the degradation of multiple cell cycle-regulated proteins to prevent genomic instability. In addition, it is critical for normal cell cycle progression by ensuring the timely destruction of various cell cycle proteins whose deregulated expression impairs cell cycle progression. Here, we summarize our current knowledge about the various roles of the CRL4Cdt2 E3 ubiquitin ligase, and how its activity contributes both to the preservation of genome integrity and to normal cell cycle progression, and how its deregulation may contribute to human cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Cycle Proteins / metabolism
  • Cell Cycle*
  • DNA Repair
  • DNA-Binding Proteins / metabolism
  • Genomic Instability
  • Humans
  • Neoplasms / metabolism
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Nuclear Proteins / physiology
  • Proliferating Cell Nuclear Antigen / metabolism
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*
  • Ubiquitin-Protein Ligases / physiology
  • Ubiquitination


  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • DTL protein, human
  • Nuclear Proteins
  • Proliferating Cell Nuclear Antigen
  • Ubiquitin-Protein Ligases