Childhood tuberculosis: epidemiology and natural history of disease

Indian J Pediatr. 2011 Mar;78(3):321-7. doi: 10.1007/s12098-010-0353-1. Epub 2011 Jan 7.


Despite previous misperceptions that childhood tuberculosis (TB) is less relevant, since children tend to develop mild disease, contribute little to transmission and do not impact epidemic control, awareness is growing that TB is an important preventable cause of disease and death among children in TB endemic areas. At an operational level there remains an urgent need for feasible and implementable policies to guide management in resource limited settings. This manuscript reviews the epidemiology and natural history of TB in children in order to improve understanding of the various disease entities encountered and to provide the rationale for different management approaches.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Age Factors
  • Child
  • Child, Preschool
  • Comorbidity
  • HIV Infections / epidemiology
  • Humans
  • Infant
  • Population Surveillance
  • Risk Factors
  • Tuberculosis / diagnosis
  • Tuberculosis / epidemiology*
  • Tuberculosis / physiopathology
  • Tuberculosis / transmission