The grape antioxidant resveratrol for skin disorders: promise, prospects, and challenges

Arch Biochem Biophys. 2011 Apr 15;508(2):164-70. doi: 10.1016/ Epub 2011 Jan 4.


Resveratrol, a phytoalexin antioxidant found in red grapes, has been shown to have both chemopreventive and therapeutic effects against many diseases and disorders, including those of the skin. Studies have shown protective effects of resveratrol against ultraviolet radiation-mediated oxidative stress and cutaneous damages including skin cancer. Because many of the skin conditions stem from ultraviolet radiation and oxidative stress, this antioxidant appears to have promise and prospects against a wide range of cutaneous disorders including skin aging and skin cancers. However, there are a few roadblocks in the way of this promising agent regarding its translation from the bench to the bedside. This review discusses the promise and prospects of resveratrol in the management of skin disorders and the associated challenges.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use*
  • Humans
  • Oxidative Stress / drug effects
  • Resveratrol
  • Skin / drug effects
  • Skin / metabolism
  • Skin Diseases / drug therapy*
  • Skin Diseases / metabolism
  • Stilbenes / pharmacology*
  • Stilbenes / therapeutic use*
  • Vitis / chemistry*


  • Antioxidants
  • Stilbenes
  • Resveratrol