Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer

Fertil Steril. 2011 May;95(6):2140-2. doi: 10.1016/j.fertnstert.2010.12.018. Epub 2011 Jan 7.

Abstract

In a 7-year (2002-2008) retrospective study of a large IVF program based on minimal ovarian stimulation and single ET (47,841 single ETs), monozygotic twinning occurred in 1.01% of 14,956 clinical pregnancies. Blastocyst culture was associated with a significantly increased monozygotic twinning risk (adjusted odds ratio, 2.04; 95% confidence interval, 1.29-4.48), whereas embryo freezing, type of stimulation protocol used, intracytoplasmic sperm injection fertilization, or zona removal did not influence its incidence.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Birth Weight
  • Blastocyst / cytology*
  • Cells, Cultured
  • Cohort Studies
  • Embryo Culture Techniques*
  • Female
  • Humans
  • Incidence
  • Infant, Newborn
  • Maternal Age
  • Pregnancy
  • Pregnancy Rate
  • Pregnancy, Multiple / statistics & numerical data*
  • Premature Birth / epidemiology
  • Retrospective Studies
  • Single Embryo Transfer / statistics & numerical data*
  • Twinning, Monozygotic* / physiology
  • Twins, Monozygotic