Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

Bioorg Med Chem. 2011 Jan 15;19(2):749-53. doi: 10.1016/j.bmc.2010.12.025. Epub 2010 Dec 13.

Abstract

Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Cell Line, Tumor
  • Heterocyclic Compounds, 4 or More Rings / chemistry*
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification
  • Humans
  • Lycopodium / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Nerve Growth Factor / genetics
  • Nerve Growth Factor / metabolism
  • RNA, Messenger / metabolism

Substances

  • Alkaloids
  • Heterocyclic Compounds, 4 or More Rings
  • RNA, Messenger
  • complanadine E
  • lyconadin D
  • lyconadin E
  • Nerve Growth Factor