Abstract
Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Cell Line, Tumor
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Heterocyclic Compounds, 4 or More Rings / chemistry*
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Heterocyclic Compounds, 4 or More Rings / isolation & purification
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Humans
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Lycopodium / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Nerve Growth Factor / genetics
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Nerve Growth Factor / metabolism
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RNA, Messenger / metabolism
Substances
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Alkaloids
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Heterocyclic Compounds, 4 or More Rings
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RNA, Messenger
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complanadine E
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lyconadin D
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lyconadin E
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Nerve Growth Factor