Axon guidance: push and pull with ephrins and GDNF

Curr Biol. 2011 Jan 11;21(1):R30-2. doi: 10.1016/j.cub.2010.11.064.

Abstract

The pathfinding of motor axons is an important model system for understanding binary axon guidance decisions. Recent work has shown that GDNF attracts motor neuron growth cones, and interacts synergistically with ephrinAs on growth cone directionality.

Publication types

  • Comment

MeSH terms

  • Animals
  • Axons / physiology*
  • Chickens
  • Ephrins / metabolism*
  • Gene Expression Regulation / physiology
  • Glial Cell Line-Derived Neurotrophic Factor / metabolism*
  • Glial Cell Line-Derived Neurotrophic Factor Receptors / physiology*
  • Mice
  • Motor Neurons / cytology*
  • Motor Neurons / physiology

Substances

  • Ephrins
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors