Mechanism and significance of cis-inhibition in Notch signalling

Curr Biol. 2011 Jan 11;21(1):R40-7. doi: 10.1016/j.cub.2010.10.034.


Notch receptors in a given cell are activated by cell surface ligands in neighbouring cells but can also be inhibited by the ligands present within the same cell. This process is known as cis-inhibition of Notch. Additionally, reciprocal cis-inhibition of the ligands by Notch has also been observed, albeit to a limited extent. Here, we review the mechanisms, functional relevance and potential implications of these cis-inhibitory interactions for Notch-mediated fate decisions.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / physiology*
  • Receptors, Notch / genetics
  • Receptors, Notch / metabolism*
  • Signal Transduction


  • Receptors, Notch