No evidence for a low linear energy transfer adaptive response in irradiated RKO cells

Radiat Prot Dosimetry. 2011 Feb;143(2-4):311-4. doi: 10.1093/rpd/ncq487. Epub 2011 Jan 6.


It has become increasingly evident from reports in the literature that there are many confounding factors capable of modulating radiation-induced non-targeted responses, such as the bystander effect and the adaptive response. In this paper, we examine recent data which suggest that the observation of non-targeted responses may not be universally observable for differing radiation qualities. We have conducted a study of the adaptive response following low-linear energy transfer exposures for human colon carcinoma cells and failed to observe adaption for the endpoints of clonogenic survival or micronucleus formation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adaptation, Physiological / radiation effects*
  • Bystander Effect / radiation effects*
  • Cell Line, Tumor
  • Cell Survival / radiation effects*
  • Colonic Neoplasms / pathology*
  • Colonic Neoplasms / physiopathology*
  • Dose-Response Relationship, Radiation
  • Humans
  • Linear Energy Transfer*
  • Radiation Dosage